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wgsim: 比较通用的序列模拟器

标题:

wgsim: Reads simulator

摘要:

Wgsim is a small tool for simulating sequence reads from a reference genome. It is able to simulate diploid genomes with SNPs and insertion/deletion (INDEL) polymorphisms, and simulate reads with uniform substitution sequencing errors. It does not generate INDEL sequencing errors, but this can be partly compensated by simulating INDEL […]

FASTQSim:高通量测序数据模拟应用,支持 illumina/ion/pacbio/roche平台

标题:

FASTQSim: platform-independent data characterization and in silico read generation for NGS datasets.

摘要:

BACKGROUND: High-throughput next generation sequencing technologies have enabled rapid characterization of clinical and environmental samples. Consequently, the largest bottleneck to actionable data has become sample processing and bioinformatics analysis, creating a need for accurate and rapid algorithms to process genetic data. […]